Amperometric Readout and Electrode Array Chip for Bioelectrochemical Sensors

As nanostructured bioelectronic interfaces continue to evolve for sensor applications, new readout circuits are needed to harness their capabilities. This paper presents a single-chip amperometric readout circuit and electrode array system suitable for bioelectrochemical measurements. The chip features a CMOS potentiostat with high resolution, range-programmable current readout and electrochemical cell potential drive circuitry, which can perform on-chip chronoamperometry and cyclic voltammetry assays. Through post-CMOS fabrication, the surface of the chip is prepared with an array of electrodes suitable for formation of bioelectronic interfaces and on-chip bioelectrochemical measurements. The 3times3mm² chip nominally hosts a 4times4 working electrode array and supports amperometric outputs ranging from 10pA to 10muA with sub-pA resolution.