Title :
Synthesis of Transcription Control with Dynamic Event-Controllability
Author_Institution :
Nat. Univ. of Singapore, Singapore
Abstract :
This paper presents a discrete-event approach to synthesis of transcription control for a class of (computational) gene networks. Given a set of genes and protein-gene and/or protein-protein interaction patterns, this approach can be used to synthesis a transcription control induced by these interaction patterns, and as a consequence, determine the behavior of the gene network. This proposed approach is demonstrated in the synthesis of a transcription control that produces the observed (logical) behavior in the induction of a phage lambda lysogen.
Keywords :
control system synthesis; controllability; discrete event systems; genetics; proteins; computational gene networks; discrete-event approach; dynamic event-controllability; phage lambda lysogen; protein-gene interaction; protein-protein interaction patterns; transcription control synthesis; Biological cells; Cells (biology); Control system synthesis; DNA; Gene expression; Genetics; Network synthesis; Organisms; Proteins; RNA;
Conference_Titel :
Systems, Man and Cybernetics, 2006. SMC '06. IEEE International Conference on
Conference_Location :
Taipei
Print_ISBN :
1-4244-0099-6
Electronic_ISBN :
1-4244-0100-3
DOI :
10.1109/ICSMC.2006.384649