Four-dimensional gated cardiac SPECT reconstruction and evaluation study

Recently we proposed a motion-compensated approach for four-dimensional (4D) reconstruction for gated cardiac single photon emission tomography (SPECT), and demonstrated that motion-compensated gate smoothing can be effective for noise reduction in the reconstructed images. In this paper we further develop our 4D approach by including attenuation and scatter compensation and evaluate it based on a more realistic Monte Carlo simulation and a set of patient data. Our results from both the simulated and patient data demonstrate that the 4D method can lead to improved reconstruction.