Title :
Kinetic modeling of PET data and FDG continuous infusion in rat tumors simultaneously treated with PDT
Author :
Bentourkia, M´hamed ; Boubacar, P. ; Berard, V. ; van Lier, J.E. ; Lecomte, Roger
Author_Institution :
Univ. de Sherbrooke, Sherbrooke
fDate :
Oct. 26 2007-Nov. 3 2007
Abstract :
The aim of this work was to assess by kinetic modeling the effects of the photodynamic therapy (PDT) of cancer in two mammary adenocarcinoma tumors implanted in the axillary areas of rats. One tumor served as control while the other was treated with red light 24 hours after administration of two types of photosensitizers: AlPcS4 and ZnPcS2. PET scans were carried on, with a continuous infusion of fluorodeoxyglucose (FDG), during 2 hours including the 30 min duration of the illumination of the tumor. The usual FDG kinetic model was modified to include the effects of the treatment. Since the blood supply to the tumors was affected by the illumination during the PET scans, the input curve was derived from factor analysis. A study of the FDG kinetic compartment model and rate constants is presented for both AlPcS4 and ZnPcS2
Keywords :
biological organs; blood; cancer; photodynamic therapy; positron emission tomography; tumours; AlPcS4 photosensitizers; FDG kinetic compartment model; PDT treatment; PET data kinetic modeling; PET scanning; ZnPcS2 photosensitizers; blood supply; fluorodeoxyglucose continuous infusion; mammary adenocarcinoma tumors; photodynamic therapy; rat axillary areas; time 2 hr; time 24 hr; time 30 min; tumor illumination; Blood; Cancer; Kinetic theory; Lighting; Medical treatment; Neoplasms; Nuclear and plasma sciences; Positron emission tomography; Rats; Tumors;
Conference_Titel :
Nuclear Science Symposium Conference Record, 2007. NSS '07. IEEE
Conference_Location :
Honolulu, HI
Print_ISBN :
978-1-4244-0922-8
Electronic_ISBN :
1095-7863
DOI :
10.1109/NSSMIC.2007.4436998
