DocumentCode :
471352
Title :
Exploring nociceptive response by BOLD fMRI in α-chloralose anesthetized rats
Author :
Shih, Yen-Yu ; Chen, You-Yin ; Chen, Jin-May ; Lung, Yun ; Chen, Jun-Ying ; Chang, Chen ; Chen, Jyh-Cheng ; Jaw, Fu-Shan
Author_Institution :
Inst. of Biomed. Eng., Nat. Taiwan Univ., Taipei
fYear :
2006
fDate :
Aug. 30 2006-Sept. 3 2006
Firstpage :
33
Lastpage :
36
Abstract :
The technique of blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) was used to provide a spatial-temporal mapping of nociceptive activation in brain. We contrived to obtain an illustration of the pain related regions by injecting formalin at the hindpaw using a 4.7 T MR system in α-chloralose anesthetized rats. In order to obtain the pain response, we avoided any invasive surgery on animals to purify the signal of nociception. The dynamic data were analyzed by mapping correlation coefficient and the time activity curves were calculated by atlas-based region of interest selection. The BOLD signals showed obvious difference in anterior cingulated cortex, somatosensory cortex, medial thalamus, and striatum after stimulation. The results not only show the global somatotopic organization of noxious stimulation on hindpaw in rats, but also provided invaluable information for neuroscience research.
Keywords :
biomedical MRI; brain; correlation methods; neurophysiology; somatosensory phenomena; spatiotemporal phenomena; 4.7 T; BOLD functional magnetic resonance imaging; alpha-chloralose; anterior cingulated cortex; atlas-based region; blood oxygenation level dependent functional MRI; brain activation; correlation coefficient; formalin; global somatotopic organization; medial thalamus; neuroscience research; nociceptive activation; nociceptive response; noxious stimulation; pain response; somatosensory cortex; spatial-temporal mapping; striatum; time activity curves; Animals; Biomedical engineering; Blood flow; Brain; Lungs; Magnetic resonance imaging; Neuroscience; Pain; Paramagnetic materials; Rats; Animals; Brain; Brain Mapping; Chloralose; Evoked Potentials, Somatosensory; Formaldehyde; Hypnotics and Sedatives; Magnetic Resonance Imaging; Male; Nociceptors; Oxygen Consumption; Pain; Pain Measurement; Rats; Rats, Wistar;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE
Conference_Location :
New York, NY
ISSN :
1557-170X
Print_ISBN :
1-4244-0032-5
Electronic_ISBN :
1557-170X
Type :
conf
DOI :
10.1109/IEMBS.2006.259508
Filename :
4461676
Link To Document :
بازگشت