Title :
Using Quantitative Imaging Techniques to Assess Vascularity in AIDS-Related Kaposi´s Sarcoma
Author :
Vogel, Abby ; Dasgeb, Bahar ; Hassan, Moinuddin ; Amyot, Franck ; Chernomordik, Victor ; Tao, Yang ; Demos, Stavros G. ; Wyvill, Kathleen ; Aleman, Karen ; Little, Richard ; Yarchoan, Robert ; Gandjbakhche, Amir H.
Author_Institution :
Lab. of Integrative & Med. Biophys., Nat. Inst. of Health, Bethesda, MD
fDate :
Aug. 30 2006-Sept. 3 2006
Abstract :
Three quantitative and non-invasive techniques were used to monitor angiogenesis in Kaposi´s sarcoma patients: thermography, laser Doppler imaging (LDI), and near-infrared spectroscopy. Before and after combination cytotoxic and anti-angiogenesis therapy, blood volume, oxygenated hemoglobin, temperature, and blood flow were analyzed. These three techniques are objective, easy to perform, and appear to be very sensitive in assessing changes in the lesions upon administration of therapy
Keywords :
biomedical measurement; biomedical optical imaging; blood vessels; cancer; haemodynamics; infrared spectroscopy; laser applications in medicine; patient treatment; proteins; tumours; AIDS-related Kaposi´s sarcoma patients; angiogenesis; anti-angiogenesis therapy; blood flow; blood volume; cytotoxic therapy; laser Doppler imaging; near-infrared spectroscopy; oxygenated hemoglobin; quantitative imaging techniques; thermography; Acquired immune deficiency syndrome; Blood; Diseases; Laboratories; Lesions; Medical treatment; Neoplasms; Skin; Spectroscopy; USA Councils; Multi-modality imaging; laser Doppler imaging; near-infrared spectroscopy; thermography;
Conference_Titel :
Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE
Conference_Location :
New York, NY
Print_ISBN :
1-4244-0032-5
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2006.259462
