Using Quantitative Imaging Techniques to Assess Vascularity in AIDS-Related Kaposi´s Sarcoma

Author

Vogel, Abby ; Dasgeb, Bahar ; Hassan, Moinuddin ; Amyot, Franck ; Chernomordik, Victor ; Tao, Yang ; Demos, Stavros G. ; Wyvill, Kathleen ; Aleman, Karen ; Little, Richard ; Yarchoan, Robert ; Gandjbakhche, Amir H.

Author_Institution

Lab. of Integrative & Med. Biophys., Nat. Inst. of Health, Bethesda, MD

fYear

2006

fDate

Aug. 30 2006-Sept. 3 2006

Firstpage

232

Lastpage

235

Abstract

Three quantitative and non-invasive techniques were used to monitor angiogenesis in Kaposi´s sarcoma patients: thermography, laser Doppler imaging (LDI), and near-infrared spectroscopy. Before and after combination cytotoxic and anti-angiogenesis therapy, blood volume, oxygenated hemoglobin, temperature, and blood flow were analyzed. These three techniques are objective, easy to perform, and appear to be very sensitive in assessing changes in the lesions upon administration of therapy

Keywords

biomedical measurement; biomedical optical imaging; blood vessels; cancer; haemodynamics; infrared spectroscopy; laser applications in medicine; patient treatment; proteins; tumours; AIDS-related Kaposi´s sarcoma patients; angiogenesis; anti-angiogenesis therapy; blood flow; blood volume; cytotoxic therapy; laser Doppler imaging; near-infrared spectroscopy; oxygenated hemoglobin; quantitative imaging techniques; thermography; Acquired immune deficiency syndrome; Blood; Diseases; Laboratories; Lesions; Medical treatment; Neoplasms; Skin; Spectroscopy; USA Councils; Multi-modality imaging; laser Doppler imaging; near-infrared spectroscopy; thermography;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE

Conference_Location

New York, NY

ISSN

1557-170X

Print_ISBN

1-4244-0032-5

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2006.259462

Filename

4461727