Title :
Imaging Cellular Calcium Dysfunction in the Heart Using Multi-Modal Optical Mapping
Author :
Hoeker, Gregory S. ; Katra, Rodolphe P. ; Laurita, Kenneth R.
Author_Institution :
Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH
fDate :
Aug. 30 2006-Sept. 3 2006
Abstract :
To study calcium mediated arrhythmogenesis, we have developed a multi-modal optical mapping system that is able to perform dual calcium voltage and ratiometric calcium optical mapping in the same cardiac preparation. To ensure physiological stability of the preparation, the ECG, coronary pressure, coronary flow, and perfusion temperature are continuously monitored throughout each experiment. The multi-modal optical mapping system has been designed so that it can be easily switched from ratiometric calcium mode to dual calcium-voltage mode. It is concluded that multi-modal optical mapping is a very powerful technique for investigating calcium mediated arrhythmogenesis
Keywords :
biochemistry; biomedical optical imaging; biothermics; calcium; cellular biophysics; diseases; electrocardiography; haemorheology; ECG; calcium mediated arrhythmogenesis; cardiac preparation; cellular calcium dysfunction imaging; coronary flow; coronary pressure; dual calcium voltage; heart dysfunction; multimodal optical mapping; perfusion temperature; physiological stability; ratiometric calcium optical mapping; Biomedical monitoring; Calcium; Electrocardiography; Heart; Optical design; Optical imaging; Stability; Temperature measurement; Temperature sensors; Voltage;
Conference_Titel :
Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE
Conference_Location :
New York, NY
Print_ISBN :
1-4244-0032-5
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2006.259732
