Atrial Action Potential Heterogeneity Measured by Unipolar Electrograms

Author

Vigmond, Edward J. ; Tsoi, Vincent ; Page, P.

Author_Institution

Dept. of Electr. & Comput. Eng., Calgary Univ., Alta.

fYear

2006

fDate

Aug. 30 2006-Sept. 3 2006

Firstpage

588

Lastpage

589

Abstract

Vagally-induced action potential duration (APD) heterogeneity can lead to the breakdown of atrial flutter into fibrillation. The exact distribution of vagal mediated effects in the atria is unknown, however. This study analyzed canine electrograms in order to determine changes in APD. Electrograms were recorded under control, and left and right vagal nerve stimulation. Simulations in a computer model were first performed in order to determine how local acetylcholine concentrations affect electrograms. Two measures were investigated to assess APD changes. Results indicate that APD is reduced nonuniformly, and contralateral effects were seen

Keywords

bioelectric potentials; diseases; electrocardiography; neurophysiology; organic compounds; acetylcholine concentration; atrial action potential heterogeneity; atrial fibrillation; atrial flutter; canine electrograms; computer model; contralateral effects; unipolar electrograms; vagal mediated effects; vagal nerve stimulation; vagally-induced action potential duration heterogeneity; Cities and towns; Computational modeling; Computer simulation; Drives; Electric breakdown; Electric variables measurement; Electrodes; Fibrillation; Static VAr compensators; USA Councils;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE

Conference_Location

New York, NY

ISSN

1557-170X

Print_ISBN

1-4244-0032-5

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2006.259830

Filename

4461818