Title :
Synthesis and Characterization of Novel Injectable, Biodegradable and In situ Crosslinkable Poly(hexamethylene-carbonate-fumarate), Poly(hexamethylene carbonate) Diacrylate and Poly(ethylene glycol fumarate-co-hexamethylene carbonate-fumarate) Scaffolds f
Author :
Sharifi, S. ; Mirzadeh, H. ; Imani, M. ; Atai, M. ; Bakhshi, R. ; Ziaee, F.
Author_Institution :
Biomed. Eng. Dept., Amirkabir Univ. of Technol., Tehran
fDate :
Aug. 30 2006-Sept. 3 2006
Abstract :
A series of novel self-crosslinkable and biodegradable polymers; poly(hexamethylene carbonate-fumarate), poly(hexamethylene carbonate) diacrylate and their amphiphilic copolymers with polyethylene glycol, poly(ethylene glycol fumarate-co-hexamethylene carbonate-fumarate) (PEGF-co-PHMCF) were developed for tissue engineering using novel synthesis approach. These novel polymers were fully characterized using nuclear magnetic resonance spectroscopy, Fourier transform infrared spectroscopy, gel permeation chromatography, differential scanning calorimetry, rheometry and shrinkage strain measurement. The cytocompatibility of macromers and their networks were evaluated by [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] MTT assay. The synthetic macromers were light colored with self-crosslinking ability via both photocrosslinking and chemical crosslinking. These polymers can be used as precursors to prepare polymer networks and scaffolds with controlled hydrophilicity, biodegradability and mechanical characteristics for application in cell delivery, tissue engineering and controlled release of biologically active agents
Keywords :
Fourier transform spectroscopy; NMR spectroscopy; biodegradable materials; bone; cellular biophysics; chromatography; differential scanning calorimetry; infrared spectroscopy; polymer blends; shrinkage; strain measurement; tissue engineering; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT assay; Fourier transform infrared spectroscopy; amphiphilic copolymers; biodegradable polymers; biologically active agents; bone tissue engineering; cell delivery; chemical crosslinking; cytocompatibility; differential scanning calorimetry; gel permeation chromatography; hydrophilicity; macromers; mechanical characteristics; nuclear magnetic resonance spectroscopy; photocrosslinking; poly(ethylene glycol fumarate-co-hexamethylene carbonate-fumarate) scaffolds; poly(hexamethylene carbonate) diacrylate scaffolds; poly(hexamethylene-carbonate-fumarate) scaffolds; polyethylene glycol; polymer characterization; polymer networks; rheometry; self-crosslinkable polymers; shrinkage strain measurement; synthesis approach; Biodegradable materials; Biological control systems; Fourier transforms; Infrared spectra; Network synthesis; Nuclear magnetic resonance; Polyethylene; Polymer gels; Spectroscopy; Tissue engineering;
Conference_Titel :
Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE
Conference_Location :
New York, NY
Print_ISBN :
1-4244-0032-5
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2006.259887