Propagation and Electrical Impedance Changes due to Ischemia, Hypoxia and Reperfusion in Mouse Hearts

Author

Liang, Qiansheng ; Sohn, Kwanghyun ; Punske, Bonnie B.

Author_Institution

Dept. of Bioeng., Utah Univ., Salt Lake City, UT

fYear

2006

fDate

Aug. 30 2006-Sept. 3 2006

Firstpage

1560

Lastpage

1563

Abstract

The purpose of this study is to quantitatively characterize major electrical markers of cardiac ischemia in normal mouse hearts to establish a set of baseline parameters for evaluation of genetically altered mouse hearts. Optical and electrical imaging techniques were coupled with impedance measurements to quantify changes induced by global ischemia. Optical and electrical mapping studies revealed the time course of conduction slowing and local inactivation during 30 minutes of ischemia or hypoxia. Measures of myocardial electrical impedance (MEI) were made during 30 and 120 minutes of global ischemia and proved to be qualitatively similar yet quantitatively distinct when compared to results reported from other mammals. The results of this study can now be applied in the analysis of genetically altered mouse hearts that are currently becoming available to help us understand cardiac death in disease

Keywords

biomedical optical imaging; cardiology; diseases; electric impedance imaging; 120 min; 30 min; cardiac ischemia; disease; electrical imaging technique; electrical markers; genetically altered mouse heart; hypoxia; impedance measurement; myocardial electrical impedance; optical imaging technique; reperfusion; Cardiac disease; Electric variables measurement; Heart; Impedance measurement; Ischemic pain; Mice; Myocardium; Optical coupling; Optical imaging; Optical propagation;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE

Conference_Location

New York, NY

ISSN

1557-170X

Print_ISBN

1-4244-0032-5

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2006.260296

Filename

4462063