DocumentCode :
471949
Title :
EONS: An Online Synaptic Modeling Platform
Author :
Bouteiller, Jean-Marie C. ; Qiu, Yumei ; Ziane, Mohammed B. ; Baudry, Michel ; Berger, Theodore W.
Author_Institution :
Dept. of Biomed. Eng., Univ. of Southern California, Los Angeles, CA
fYear :
2006
fDate :
Aug. 30 2006-Sept. 3 2006
Firstpage :
4155
Lastpage :
4158
Abstract :
Chemical synapses, although representing the smallest unit of communication between two neurons in the nervous system constitute a complex ensemble of mechanisms. Understanding these mechanisms and the way synaptic transmission occurs is critical for our comprehension of CNS functions in general and learning and memory in particular. Here we describe a modeling platform called EONS (Elementary Object of Neural System) accessible online, which allows neuroscientists throughout the world to study qualitatively, but also quantitatively the relative contributions of diverse mechanisms underlying synaptic efficacy: the relevance of each and every elements that comprise a synapse, the interactions between these components and their subcellular distribution, as well as the influence of synaptic geometry (presynaptic terminal, cleft and postsynaptic density)
Keywords :
cellular biophysics; graphical user interfaces; medical computing; neurophysiology; EONS; chemical synapses; elementary object of neural system; graphical interface; learning; memory; nervous system; neurons communication; online synaptic modeling platform; postsynaptic density; presynaptic terminal; subcellular distribution; synaptic efficacy; synaptic geometry; synaptic transmission; Biological system modeling; Biology computing; Biomedical engineering; Calcium; Chemical elements; Computational biology; Geometry; Kinetic theory; Neurons; Neurotransmitters;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE
Conference_Location :
New York, NY
ISSN :
1557-170X
Print_ISBN :
1-4244-0032-5
Electronic_ISBN :
1557-170X
Type :
conf
DOI :
10.1109/IEMBS.2006.260693
Filename :
4462716
Link To Document :
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