Effects of Acute Hippocampal Stimulation on EEG Dynamics

Author

Nair, Sandeep P. ; Sackellares, J. Chris ; Shiau, Deng-Shan ; Norman, Wendy M. ; Dance, Linda K. ; Pardalos, Panos M. ; Principe, Jose C. ; Carney, Paul R.

Author_Institution

Dept. of Biomed. Eng., Florida Univ., Gainesville, FL

fYear

2006

fDate

Aug. 30 2006-Sept. 3 2006

Firstpage

4382

Lastpage

4386

Abstract

Progressive preictal dynamical convergence and postictal divergence of dynamical EEG descriptors among brain regions has been reported in human temporal lobe epilepsy (TLE) and in a rodent model of TLE. There are also reports of anticonvulsant effects of high frequency stimulation of the hippocampus in humans. We postulate that this anticonvulsant effect is due to dynamical resetting by the electrical stimulation. The following study investigated the effects of acute hippocampal electrical stimulation on dynamical transitions in the brain of a spontaneously seizing animal model of TLE to test the hypothesis of divergence in dynamical values by electrical stimulation of the hippocampus

Keywords

bioelectric phenomena; diseases; electroencephalography; neurophysiology; EEG dynamics; acute hippocampal electrical stimulation; anticonvulsant effects; brain region; high frequency stimulation; human temporal lobe epilepsy; postictal dynamical divergence; preictal dynamical convergence; Brain modeling; Convergence; Electrical stimulation; Electroencephalography; Epilepsy; Frequency; Hippocampus; Humans; Rodents; Temporal lobe;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE

Conference_Location

New York, NY

ISSN

1557-170X

Print_ISBN

1-4244-0032-5

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2006.260830

Filename

4462773