Analysis on dynamic pressure-volume (P-V) - relations for reliable prediction of chamber remodelling in patients with acute myocardial infarction (AMI)

A self-developed program that analyzed the load- independent LV pressure-volume (P-V) data from acute myocardial infarcted (AMI) patients to examine the process of chamber remodeling was reported. The extracted pressure-volume relationship at first week was compared to the 12 week data after PTCA procedure. The analysis program extracted static and dynamic parameters from ventricular pressure and volume acquired from catheter. The static parameters are stroke volume (SV), ejection fraction (EF), arterial elastance (Ea), the index of LV relaxation constant (tau, Tau) and many others. The dynamic parameters are the index of LV elasticity, the end systolic pressure volume relationship (ESPVR), and the constant for myocardial compliance, the end diastolic pressure volume relationship (EDPVR). At the 12th week after PTCA, the value of tau was significantly increased in comparison to the value at the 1st week. The index of LV compliance was significantly decreased at the 12th week after PTCA in comparison to the value at the 0th week. The index of arterial elasticity (Ea) was significantly decreased This result suggests that with the good recovery of myocardial compliance in relaxation phase and the fast release of LV pressure at the end of systole, the arterial impedance was adjusted significantly that prevents the development of chamber remodeling.