Title :
Electrocardiographic method for identifying moxifloxacin-induced ventricular repolarization abnormalities
Author :
Couderc, J.P. ; Vaglio, M. ; Xia, X. ; McNitt, S. ; Hyrien, O. ; Zareba, W. ; Moss, A.J.
Author_Institution :
Med. Center, Univ. of Rochester, Rochester, NY
Abstract :
We developed a new technique for the measurements of repolarization abnormalities from surface ECGs; this method improves sensitivity and specificity of the current technique used to identify the presence of a drug called moxifloxacin. This drug is used as a positive control compound in clinical studies investigating the level of drug cardiotoxicity related to the ventricular repolarization process. We describe a new technology and the preliminary results revealing the superiority of our technique in comparison to QT interval prolongation. This technology may play an important role in the future of drug-safety assessment.
Keywords :
cardiology; drugs; electrocardiography; QT interval prolongation; drug cardiotoxicity; drug-safety assessment; electrocardiography; moxifloxacin; positive control compound; surface ECG; ventricular repolarization abnormalities; Cardiology; Current measurement; Delay; Drugs; Electrocardiography; Food technology; Heart rate interval; Pharmaceutical technology; Sensitivity and specificity; Singular value decomposition;
Conference_Titel :
Computers in Cardiology, 2006
Conference_Location :
Valencia
Print_ISBN :
978-1-4244-2532-7