A three-dimensional model of canine cardiac ventricular wall electrophysiology

We have developed a three-dimensional computational wedge model of canine cardiac ventricular wall electro-physiology that incorporates biophysically detailed, spatially heterogeneous excitation, and high-resolution geometry and fibre orientation. Isolated cell model electrophysiological characteristics reproduce the experimentally observed characteristics under control conditions, and under conditions of bradycardia, with the application of a class III antiarrhythmic drug, and during simulation of long-QT syndrome 2. Propagation of excitation through the ventricular wall and the subsequent dispersion of repolarisation also reproduce experimentally observed behaviour under the same four conditions. The model therefore provides a tool for the computational study of the mechanisms underlying cardiac arrhythmias.