Terahertz pulsed imaging as an analytical tool for tablet coating quality

Author

Ho, L. ; Muller, R. ; Romer, M. ; Gordon, K.C. ; Heinamaki, J. ; Kleinebudde, P. ; Pepper, M. ; Rades, T. ; Shen, Y.C. ; Strachan, C.J. ; Taday, P.F. ; Zeitler, J.A.

Author_Institution

Sch. of Pharmacy, Univ. of Otago, Dunedin

fYear

2007

fDate

2-9 Sept. 2007

Firstpage

561

Lastpage

562

Abstract

Various aspects of tablet coating quality were analysed with terahertz pulsed imaging (TPI). Coating layer thickness variability and reproducibility, coating distribution and uniformity were determined and validated with optical microscopy imaging. Results indicated that TPI has the potential to be employed as a process analytical tool to determine tablet coating quality due to its non-destructive nature.

Keywords

optical microscopy; pharmaceutical industry; refractive index measurement; submillimetre wave imaging; thickness measurement; coating distribution; coating layer thickness variability; optical microscopy imaging; tablet coating quality; terahertz pulsed imaging; Biomedical optical imaging; Coatings; Image analysis; Instruments; Optical imaging; Optical microscopy; Optical pulses; Pharmaceutical technology; Reproducibility of results; Submillimeter wave technology;

fLanguage

English

Publisher

ieee

Conference_Titel

Infrared and Millimeter Waves, 2007 and the 2007 15th International Conference on Terahertz Electronics. IRMMW-THz. Joint 32nd International Conference on

Conference_Location

Cardiff

Print_ISBN

978-1-4244-1438-3

Type

conf

DOI

10.1109/ICIMW.2007.4516629

Filename

4516629