Title :
Detection of tulobuterol crystal in transdermal tapes using terahertz pulsed spectroscopy and imaging
Author :
Sakamoto, Tomoaki ; Portieri, Alessia ; Taday, Philip F. ; Sasakura, Daisuke ; Terahara, Takaaki ; Miura, Tsuyoshi ; Higo, Naruhito ; Arnone, Donald D. ; Hiyama, Yukio
Author_Institution :
Div. of Drugs, Nat. Inst. of Health Sci., Tokyo
Abstract :
Applicability of the terahertz pulsed spectroscopy (TPS) and the terahertz pulsed imaging (TPI) to detect tulobuterol (TBR) crystal in transdermal tape has been investigated. The TBR crystal was identified by comparison between spectrum of tapes and TBR reference standard. The TBR crystal in patch matrix was successfully detected by the TPS and TPI. These results indicate that the TPS and TPI are applicable to identify an active substance in patch matrix for quality control.
Keywords :
patient diagnosis; skin; submillimetre wave imaging; submillimetre wave spectroscopy; patch matrix; quality control; terahertz pulsed imaging; terahertz pulsed spectroscopy; transdermal tapes; tulobuterol crystal detection; Chemical technology; Crystals; Optical imaging; Optical pulses; Pharmaceutical technology; Pulse measurements; Spatial resolution; Spectroscopy; Thickness measurement; Time measurement;
Conference_Titel :
Infrared and Millimeter Waves, 2007 and the 2007 15th International Conference on Terahertz Electronics. IRMMW-THz. Joint 32nd International Conference on
Conference_Location :
Cardiff
Print_ISBN :
978-1-4244-1438-3
DOI :
10.1109/ICIMW.2007.4516633
