Title :
Using terahertz time-domain spectroscopy to identify pharmaceutical cocrystals
Author :
Parrott, E.P.J. ; Nguyen, K. Lien ; Friscic, T. ; Zeitler, J.A. ; Pepper, Michael ; Jones, W. ; Gladden, Lynn F.
Author_Institution :
Dept. of Chem. Eng., Univ. of Cambridge, Cambridge
Abstract :
The conversion of polycrystalline pharmaceutical materials into their cocrystals has been monitored using terahertz (THz) spectroscopy. Eight cocrystal systems have been studied and their THz spectra were found to exhibit differences from the constituent materials. Cocrystals of theophylline and DL and L forms of malic acid were clearly differentiated using THz spectroscopy while powder X-ray diffraction (PXRD) results were less conclusive.
Keywords :
crystals; pharmaceuticals; submillimetre wave spectra; THz spectra; THz spectroscopy; cocrystal systems; malic acid; pharmaceutical cocrystals identification; polycrystalline pharmaceutical materials; powder X-ray diffraction; terahertz time-domain spectroscopy; theophylline; Chemical engineering; Chemistry; Crystallization; Laboratories; Monitoring; Pharmaceuticals; Platinum; Solid state circuits; Spectroscopy; Time domain analysis;
Conference_Titel :
Infrared and Millimeter Waves, 2007 and the 2007 15th International Conference on Terahertz Electronics. IRMMW-THz. Joint 32nd International Conference on
Conference_Location :
Cardiff
Print_ISBN :
978-1-4244-1438-3
DOI :
10.1109/ICIMW.2007.4516670
