Using terahertz time-domain spectroscopy to identify pharmaceutical cocrystals

Author

Parrott, E.P.J. ; Nguyen, K. Lien ; Friscic, T. ; Zeitler, J.A. ; Pepper, Michael ; Jones, W. ; Gladden, Lynn F.

Author_Institution

Dept. of Chem. Eng., Univ. of Cambridge, Cambridge

fYear

2007

fDate

2-9 Sept. 2007

Firstpage

660

Lastpage

661

Abstract

The conversion of polycrystalline pharmaceutical materials into their cocrystals has been monitored using terahertz (THz) spectroscopy. Eight cocrystal systems have been studied and their THz spectra were found to exhibit differences from the constituent materials. Cocrystals of theophylline and DL and L forms of malic acid were clearly differentiated using THz spectroscopy while powder X-ray diffraction (PXRD) results were less conclusive.

Keywords

crystals; pharmaceuticals; submillimetre wave spectra; THz spectra; THz spectroscopy; cocrystal systems; malic acid; pharmaceutical cocrystals identification; polycrystalline pharmaceutical materials; powder X-ray diffraction; terahertz time-domain spectroscopy; theophylline; Chemical engineering; Chemistry; Crystallization; Laboratories; Monitoring; Pharmaceuticals; Platinum; Solid state circuits; Spectroscopy; Time domain analysis;

fLanguage

English

Publisher

ieee

Conference_Titel

Infrared and Millimeter Waves, 2007 and the 2007 15th International Conference on Terahertz Electronics. IRMMW-THz. Joint 32nd International Conference on

Conference_Location

Cardiff

Print_ISBN

978-1-4244-1438-3

Type

conf

DOI

10.1109/ICIMW.2007.4516670

Filename

4516670