DocumentCode
478153
Title
Notice of Retraction
Study of the Plasma Metabolic Phenotype in Rats with Chronic Immobilization Stress
Author
Jiaxu Chen ; Hegu Luo ; Xin Zhao ; Guangxing Yue ; Jie Ding ; Yuan Liang
Author_Institution
Beijing Univ. of Chinese Med., Beijing
Volume
2
fYear
2008
fDate
18-20 Oct. 2008
Firstpage
665
Lastpage
669
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
To determine changes in the plasma metabolic phenotype in rats with chronic immobilization stress (CIS), and attempt to interpretation of metabonomic changes in the rats induced by CIS via determination of characteristic metabolic products and discovery of biomarkers in the rats. Blood was collected from the cardioventricle under anesthesia and detected by using the Fourier variable superconducting nuclear magnetic resonance (NMR) spectrometer. The results showed: the PCA analysis of rat plasma 1H NMR spectra revealed different metabolic spectra between stress and control groups, which was consistent with alterations of in vivo metabolisms in rats under stress stimuli. It can be concluded that: the metabolic phenotype of CIS includes increases in plasma levels of lactic acid, choline, NAC, saturated fatty acid, and decreases in the levels of unsaturated fatty acid, blood sugar, HDL, and the unknown compounds (3.44 ppm). These metabolic components also may be the biomarkers of metabolites induced by CIS.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
To determine changes in the plasma metabolic phenotype in rats with chronic immobilization stress (CIS), and attempt to interpretation of metabonomic changes in the rats induced by CIS via determination of characteristic metabolic products and discovery of biomarkers in the rats. Blood was collected from the cardioventricle under anesthesia and detected by using the Fourier variable superconducting nuclear magnetic resonance (NMR) spectrometer. The results showed: the PCA analysis of rat plasma 1H NMR spectra revealed different metabolic spectra between stress and control groups, which was consistent with alterations of in vivo metabolisms in rats under stress stimuli. It can be concluded that: the metabolic phenotype of CIS includes increases in plasma levels of lactic acid, choline, NAC, saturated fatty acid, and decreases in the levels of unsaturated fatty acid, blood sugar, HDL, and the unknown compounds (3.44 ppm). These metabolic components also may be the biomarkers of metabolites induced by CIS.
Keywords
biochemistry; biomedical NMR; blood; principal component analysis; proton magnetic resonance; spectrochemical analysis; superconducting devices; Fourier variable superconducting nuclear magnetic resonance; HDL; NAC; NMR spectrometer; PCA analysis; anesthesia; biomarkers; blood sugar; cardioventricle; choline; chronic immobilization stress; in vivo metabolism; lactic acid; metabonomic changes; plasma metabolic phenotype; rat plasma 1H NMR spectra; saturated fatty acid; unsaturated fatty acid; Anesthesia; Biomarkers; Blood; Cardiology; Computational Intelligence Society; Nuclear magnetic resonance; Plasma properties; Rats; Spectroscopy; Stress;
fLanguage
English
Publisher
ieee
Conference_Titel
Natural Computation, 2008. ICNC '08. Fourth International Conference on
Conference_Location
Jinan
Print_ISBN
978-0-7695-3304-9
Type
conf
DOI
10.1109/ICNC.2008.123
Filename
4667077
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