• DocumentCode
    488470
  • Title

    Control of Fed-Batch Culture of Hybridoma Cells for Monoclonal Antibody Production

  • Author

    de Tremblay, Michele ; Perrier, Michel ; Chavarie, Claude ; Archambault, Jean

  • Author_Institution
    Biotechnology Research Institute, 6100 Royalmount Ave., Montréal, Québec, Canada H4P 2R2; Ecole Polytechnique de Montréal, Department of Chemical Engineering
  • fYear
    1990
  • fDate
    23-25 May 1990
  • Firstpage
    2150
  • Lastpage
    2155
  • Abstract
    Control of fed-batch culture of hybridoma cells was investigated from two approaches: optimal control theory and feedback control. Optimal control policy generated a higher concentration of MAb experimentally than the feedback approach for the chosen set-point. In both cases, the viability of the cells is lower than the model predictions.
  • Keywords
    Amino acids; Animals; Biotechnology; Chemical engineering; Dynamic programming; Feedback control; Feeds; Mass production; Optimal control; Sugar;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    American Control Conference, 1990
  • Conference_Location
    San Diego, CA, USA
  • Type

    conf

  • Filename
    4791111
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=488470