The Application of Apriori-Gen Algorithm on the Interaction Analysis of SNPs in Genetic Disease

Author

Mao, Weidong

Author_Institution

Dept. of Math. & Comput. Sci., Virginia State Univ., Petersburg, VA, USA

Volume

3

fYear

2009

fDate

March 31 2009-April 2 2009

Firstpage

626

Lastpage

630

Abstract

Gene-gene interaction analyses have been used to identify common disease susceptibility genes. Recently, evidence of a statistical interaction among several SNPs has been reported in Crohn´s disease. This paper explores the application of apriori-gen algorithm on the association study in Crohn´s disease. The Apriori-Gen algorithm has been applied to SNP data of Crohn´s disease for association study. The result shows the interaction among 5 SNPs with support of 50% and confidence of 60%. The relative risk RR and odds ratio OR are 1.98 and 2.59, respectively. The experiment results indicate that the interaction among those SNPs is responsible for the disease.

Keywords

biology computing; diseases; genetics; Crohn disease; SNP; apriori-gen algorithm; gene-gene interaction; genetic disease; interaction analysis; regional enteritis; Algorithm design and analysis; Application software; Bioinformatics; Computer science; DNA; Diseases; Genetics; Genomics; Humans; Information analysis; Apriori-Gen algorithm; association study; odds ratio; relative risk;

fLanguage

English

Publisher

ieee

Conference_Titel

Computer Science and Information Engineering, 2009 WRI World Congress on

Conference_Location

Los Angeles, CA

Print_ISBN

978-0-7695-3507-4

Type

conf

DOI

10.1109/CSIE.2009.15

Filename

5170916