Title :
Real-time, label-free protein binding detection with a one dimensional photonic crystal sensor
Author :
Guo, Yunbo ; Thomas, Thommey P. ; Ye, Jing Yong ; Myc, Andrzej ; Baker, James R., Jr. ; Norris, Theodore B.
Author_Institution :
Center for Ultrafast Opt. Sci., Univ. of Michigan, Ann Arbor, MI, USA
Abstract :
A one-dimensional photonic crystal structure in a total-internal-reflection geometry has been developed for real-time, label-free specific protein binding detection. With the streptavidin-biotin system, an ultra low mass density detection limit 24 fg/mm2 was achieved.
Keywords :
biological techniques; chemical sensors; light reflection; molecular biophysics; optical sensors; photonic crystals; proteins; label-free detection; one dimensional photonic crystal sensor; protein binding detection; real-time detection; streptavidin-biotin system; total-internal-reflection geometry; ultra low mass density detection limit; Biomedical optical imaging; Biosensors; Optical buffering; Optical resonators; Optical sensors; Optoelectronic and photonic sensors; Photonic crystals; Proteins; Resonance; Ultrafast optics; (230.5298) Photonic crystals; (260.6970) Total internal reflection; (280.1415) Biological sensing and sensors;
Conference_Titel :
Lasers and Electro-Optics, 2009 and 2009 Conference on Quantum electronics and Laser Science Conference. CLEO/QELS 2009. Conference on
Conference_Location :
Baltimore, MD
Print_ISBN :
978-1-55752-869-8
Electronic_ISBN :
978-1-55752-869-8
