Real-time, label-free protein binding detection with a one dimensional photonic crystal sensor

Author

Guo, Yunbo ; Thomas, Thommey P. ; Ye, Jing Yong ; Myc, Andrzej ; Baker, James R., Jr. ; Norris, Theodore B.

Author_Institution

Center for Ultrafast Opt. Sci., Univ. of Michigan, Ann Arbor, MI, USA

fYear

2009

fDate

2-4 June 2009

Firstpage

1

Lastpage

2

Abstract

A one-dimensional photonic crystal structure in a total-internal-reflection geometry has been developed for real-time, label-free specific protein binding detection. With the streptavidin-biotin system, an ultra low mass density detection limit 24 fg/mm² was achieved.

Keywords

biological techniques; chemical sensors; light reflection; molecular biophysics; optical sensors; photonic crystals; proteins; label-free detection; one dimensional photonic crystal sensor; protein binding detection; real-time detection; streptavidin-biotin system; total-internal-reflection geometry; ultra low mass density detection limit; Biomedical optical imaging; Biosensors; Optical buffering; Optical resonators; Optical sensors; Optoelectronic and photonic sensors; Photonic crystals; Proteins; Resonance; Ultrafast optics; (230.5298) Photonic crystals; (260.6970) Total internal reflection; (280.1415) Biological sensing and sensors;

fLanguage

English

Publisher

ieee

Conference_Titel

Lasers and Electro-Optics, 2009 and 2009 Conference on Quantum electronics and Laser Science Conference. CLEO/QELS 2009. Conference on

Conference_Location

Baltimore, MD

Print_ISBN

978-1-55752-869-8

Electronic_ISBN

978-1-55752-869-8

Type

conf

Filename

5225429