Title :
Highly multiplexed antibody-antigen detection using nanoscale optofluidic resonators
Author :
Mandal, Sudeep ; Goddard, Julie ; Erickson, David
Author_Institution :
Sch. of Appl. & Eng. Phys., Cornell Univ., Ithaca, NY, USA
Abstract :
We demonstrate a highly multiplexable optofluidic biosensor consisting of arrays of evanescently coupled photonic crystal resonators. We show the ability to monitor binding kinetics of Anti-Streptavidin in real-time and investigate the limit-of-detection (LOD) of the sensor.
Keywords :
biochemistry; biological techniques; biosensors; integrated optics; molecular biophysics; nanofluidics; nanophotonics; nanosensors; optical arrays; optical resonators; photonic crystals; proteins; anti-streptavidin; antibody-antigen detection; binding kinetics; evanescent coupling; limit-of-detection; multiplexable optofluidic biosensor; nanoscale optofluidic resonators; photonic crystal resonators; Biosensors; Kinetic theory; Monitoring; Optical resonators; Optical sensors; Optoelectronic and photonic sensors; Photonic crystals; Resonance; Sensor arrays; Sensor phenomena and characterization; (050.5298) Photonic crystals; (130.3120) Integrated optics devices; (230.7370) Waveguides; (280.4788) Optical sensing and sensors;
Conference_Titel :
Lasers and Electro-Optics, 2009 and 2009 Conference on Quantum electronics and Laser Science Conference. CLEO/QELS 2009. Conference on
Conference_Location :
Baltimore, MD
Print_ISBN :
978-1-55752-869-8
Electronic_ISBN :
978-1-55752-869-8
