Murine Heart Volume: Numerical Comparison and Calibration of Conductance Catheter Models

Author

Popa, Sorin ; Fricke, Kyle ; Dubois, Jonathan ; Kottam, Anil T. G. ; Sobot, Robert

Author_Institution

Dept. of Electr. & Comput. Eng., Western Univ., London, ON, Canada

Volume

61

Issue

9

fYear

2014

fDate

Sept. 2014

Firstpage

2396

Lastpage

2405

Abstract

A full set of finite-element method (FEM) studies of the catheter within a cylindrical cuvette and within an elliptical cuvette are presented along with novel insight on the fundamental electromagnetic properties of the catheter. An in vitro experiment with modified small mouse pressure-volume catheters was conducted and the results are presented as a validation of the FEM models. In addition, sensitivity analysis on the electrode size and position is conducted and the results allow for a novel calibration factor based on catheter geometry to be presented. This calibration factor is used in conjunction with Wei´s conductance volume equations to reduce the average measured error in cuvette volume measurements from 26.5% to 5%.

Keywords

bioelectric potentials; biomedical electrodes; biomedical measurement; calibration; cardiology; catheters; electric admittance measurement; electromagnetism; finite element analysis; geometry; measurement errors; physiological models; sensitivity analysis; FEM model validation; FEM study; Wei conductance volume equations; average measured error reduction; calibration factor; catheter geometry; conductance catheter model calibration; cuvette volume measurements; cylindrical cuvette; electrode position sensitivity analysis; electrode size sensitivity analysis; electromagnetic properties; elliptical cuvette; finite element method; in vitro experiment; modified small mouse pressure-volume catheters; murine heart volume; numerical comparison; Biomedical measurement; Blood; Catheters; Electrodes; Equations; Mathematical model; Volume measurement; Conductance-based catheter; electromagnetic simulation; finite-element method (FEM); murine heart; pressure??volume; sensitivity analysis; sensor calibration;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/TBME.2014.2313621

Filename

6778025