Near-infrared autofluorescence imaging for colonic cancer detection

Author

Shao, Xiaozhuo ; Zheng, Wei ; Huang, Zhiwei

Author_Institution

Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore 117576

Volume

2009-Supplement

fYear

2009

fDate

2-6 Nov. 2009

Firstpage

1

Lastpage

5

Abstract

We explore an NIR autofluorescence imaging technique for cancer diagnosis and detection. A set of tissue images including NIR white light images, autofluorescence (AF) images and fluorescence polarized images (FPI) (parallel-, and perpendicular- polarization) were acquired in tandem on human colonic tissues. The results show that NIR fluorescence intensity of normal tissue is significantly higher than that of cancer tissue. The perpendicular-polarization image yields the highest diagnostic accuracy 93% compared to other imaging modes. This work demonstrates that Fluorescence polarization imaging (FPI) technique has great potential for cancer diagnosis and detection in the colon.

Keywords

Biomedical optical imaging; Cancer detection; Colon; Endoscopes; Fluorescence; Laser excitation; Lesions; Optical imaging; Optical polarization; Optical sensors; Near-infrared; autofluorescence image; colon cancer;

fLanguage

English

Publisher

ieee

Conference_Titel

Communications and Photonics Conference and Exhibition (ACP), 2009 Asia

Conference_Location

Shanghai, China

Print_ISBN

978-1-55752-877-3

Electronic_ISBN

978-1-55752-877-3

Type

conf

Filename

5405618