Title :
Near-infrared autofluorescence imaging for colonic cancer detection
Author :
Shao, Xiaozhuo ; Zheng, Wei ; Huang, Zhiwei
Author_Institution :
Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore 117576
Abstract :
We explore an NIR autofluorescence imaging technique for cancer diagnosis and detection. A set of tissue images including NIR white light images, autofluorescence (AF) images and fluorescence polarized images (FPI) (parallel-, and perpendicular- polarization) were acquired in tandem on human colonic tissues. The results show that NIR fluorescence intensity of normal tissue is significantly higher than that of cancer tissue. The perpendicular-polarization image yields the highest diagnostic accuracy 93% compared to other imaging modes. This work demonstrates that Fluorescence polarization imaging (FPI) technique has great potential for cancer diagnosis and detection in the colon.
Keywords :
Biomedical optical imaging; Cancer detection; Colon; Endoscopes; Fluorescence; Laser excitation; Lesions; Optical imaging; Optical polarization; Optical sensors; Near-infrared; autofluorescence image; colon cancer;
Conference_Titel :
Communications and Photonics Conference and Exhibition (ACP), 2009 Asia
Conference_Location :
Shanghai, China
Print_ISBN :
978-1-55752-877-3
Electronic_ISBN :
978-1-55752-877-3
