Title :
Clinical diagnosis of oral submucous fibrosis with optical coherence tomography
Author :
Lee, Cheng-Kuang ; Tsai, Meng-Tsan ; Yang, C.C. ; Chiang, Chun-Pin
Author_Institution :
Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei, 10617 Taiwan
Abstract :
A swept-source optical coherence tomography (SS-OCT) system with a specially designed probe is built for clinical scanning of oral submucous fibrosis (OSF) patients. By analysing 44 OSF cases of SS-OCT scanning results, two indicators, including epithelium (EP) thickness and standard deviation (SD) of A-mode scan intensity in the laminar propria (LP) layer, are found useful for real-time OSF diagnosis. Statistics show that sensitivity and specificity of LP SD can reach 84.1 and 95.5 %, respectively. Also, both sensitivity and specificity of EP thickness can reach 100 %.
Keywords :
Biomedical optical imaging; Cancer; Clinical diagnosis; Fibroblasts; Humans; Mouth; Optical sensors; Photonics; Production; Tomography; Optical coherence tomography; medical and biological imaging; oral submucous fibrosis;
Conference_Titel :
Communications and Photonics Conference and Exhibition (ACP), 2009 Asia
Conference_Location :
Shanghai, China
Print_ISBN :
978-1-55752-877-3
Electronic_ISBN :
978-1-55752-877-3
