Modulation of the SDF-1α-CXCR4 axis for regulation of subgranular layer neural stem cells

Author

Chaudhuri, S. ; Morrison, B., III

Author_Institution

Dept. of Biomed. Eng., Columbia Univ., New York, NY, USA

fYear

2010

fDate

26-28 March 2010

Firstpage

1

Lastpage

2

Abstract

SDF-1α has been implicated in the post-traumatic neuroinflammatory cascade. We quantified the effect of SDF-1α on neural stem cell proliferation and differentiation. We found that the SDF-1α-CXCR4 axis can be manipulated so that the proliferative capacity of this chemokine can be separated and controlled. We have successfully modulated the proliferative activity of SDF-1α by preventing its binding to CXCR4. However this is an all-or-nothing approach. To achieve more precise modulation in future experiments, we will employ agonists and antagonists that modulate the downstream targets of this chemokine.

Keywords

cellular biophysics; molecular biophysics; neurophysiology; proteins; SDF-1α-CXCR4 axis modulation; chemokine; neural stem cell differentiation; neural stem cell proliferation; post traumatic neuroinflammatory cascade; subgranular layer neural stem cell regulation; Biomedical engineering; Brain cells; Brain injuries; Circuits; Hippocampus; In vitro; Inhibitors; Neurons; Proteins; Stem cells;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, Proceedings of the 2010 IEEE 36th Annual Northeast

Conference_Location

New York, NY

Print_ISBN

978-1-4244-6879-9

Type

conf

DOI

10.1109/NEBC.2010.5458116

Filename

5458116