DocumentCode
527171
Title
Notice of Retraction
The effect of Sargassum fusiforme polysaccharides on the functioning of erythrocyte membrane of S180 mice by affecting Ca2+ channels
Author
Chen feng Ji ; Yu Bin Ji ; Lei Yue ; Shi Yong Gao
Author_Institution
Eng. Res. Center on Natural Antineoplastic Drugs of Educ. Minist., Harbin Univ. of Commerce, Harbin, China
Volume
3
fYear
2010
fDate
17-18 July 2010
Firstpage
731
Lastpage
735
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
To analyze the effect of Sargassum fusiforme polysaccharides (SFPS) on the functioning of erythrocyte membrane of S180 mice by affecting Ca2+ channels. A tumor mouse model was developed, and the mice were treated with high, medium, and low doses of SFPS. Changes in [Ca2+] in the erythrocytes in the tumor-bearing mice were measured using laser confocal scanning; changes in the content of sialic acid and the acitivities of ATPase were meausred using relevant test kits; changes in the level of erythrocyte membrane potential were analyzed using FCM; and changes in the complex mobility of erythrocytes were measured using HPCE. SFPS lowered the intracelluar [Ca2+] of erythrocytes in tumor-bearing mice, increased the content of sialic acid on surface of erythrocyte membrane, increased the acitivities of Na+,K+-ATPase and Ca2+, Mg2+-ATPase, and raised the level of erythrocyte membrane potential and the complex mobility of erythrocytes in elelctrophoresis. By affecting the Ca2+ channels, SFPS can increase the content of sialic acid on the surface of erythrocyte membrane. The sialic acid combines with Ca2+ to increase the activities of Na+,K+-ATPase and Ca2+, Mg2+-ATPase, resulting in a rise in the membrane potential of the erythrocytes and an increase in the complex mobility of the erythrocytes in electrophoresis, thus restoring many physiological and biochemical functions of the e- ythrocyte membrane. This may be one of the anti-tumor mechanisms of SFPS.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
To analyze the effect of Sargassum fusiforme polysaccharides (SFPS) on the functioning of erythrocyte membrane of S180 mice by affecting Ca2+ channels. A tumor mouse model was developed, and the mice were treated with high, medium, and low doses of SFPS. Changes in [Ca2+] in the erythrocytes in the tumor-bearing mice were measured using laser confocal scanning; changes in the content of sialic acid and the acitivities of ATPase were meausred using relevant test kits; changes in the level of erythrocyte membrane potential were analyzed using FCM; and changes in the complex mobility of erythrocytes were measured using HPCE. SFPS lowered the intracelluar [Ca2+] of erythrocytes in tumor-bearing mice, increased the content of sialic acid on surface of erythrocyte membrane, increased the acitivities of Na+,K+-ATPase and Ca2+, Mg2+-ATPase, and raised the level of erythrocyte membrane potential and the complex mobility of erythrocytes in elelctrophoresis. By affecting the Ca2+ channels, SFPS can increase the content of sialic acid on the surface of erythrocyte membrane. The sialic acid combines with Ca2+ to increase the activities of Na+,K+-ATPase and Ca2+, Mg2+-ATPase, resulting in a rise in the membrane potential of the erythrocytes and an increase in the complex mobility of the erythrocytes in electrophoresis, thus restoring many physiological and biochemical functions of the e- ythrocyte membrane. This may be one of the anti-tumor mechanisms of SFPS.
Keywords
biochemistry; bioelectric phenomena; biomedical materials; biomedical measurement; biomembrane transport; cellular biophysics; electrophoresis; enzymes; molecular biophysics; patient treatment; polymers; tumours; ATPase acitivity; Ca2+ channels; Ca2+,Mg2+-ATPase; Na+,K+-ATPase; S180 mice; SFPS antitumor mechanisms; SFPS dose; Sargassum fusiforme polysaccharide effect; biochemical functions; elelctrophoresis; erythrocyte complex mobility; erythrocyte intracelluar [Ca2+]; erythrocyte membrane function; erythrocyte membrane potential; laser confocal scanning; sialic acid; tumor mouse model; tumor-bearing mice; Biomembranes; Blood; Cells (biology); Electric potential; Ions; Mice; Tumors; Ca2+; Sargassum fusiforme; erythrocyte; polysaccharides;
fLanguage
English
Publisher
ieee
Conference_Titel
Environmental Science and Information Application Technology (ESIAT), 2010 International Conference on
Conference_Location
Wuhan
Print_ISBN
978-1-4244-7387-8
Type
conf
DOI
10.1109/ESIAT.2010.5568424
Filename
5568424
Link To Document