Absolute glucose concentration measurement with a fiber-type sensing system

A fiber-type glucose sensing system is presented which combined single-mode fiber conjugated with glucose oxidase (GOD) and heterodyne interferometry. Based on the optical setup, the absolute glucose concentration can be obtained by measuring the phase difference coming from the chemical reaction between the glucose and GOD on the fiber sensor. Cause of the achievement of the absolute glucose concentration measurement, the calibration curve would not be changed with the sensor replaced. According to our results, we believe that the high sensitivity can be achieved.