Title :
Model reduction of biochemical networks
Author :
Liu, Yen-Chang ; Lin, Chun-Liang
Author_Institution :
Dept. of Electr. Eng., Nat. Chung Hsing Univ., Taichung, Taiwan
Abstract :
Biochemical networks are not only complex but also extremely large. The construction and analysis for the mathematical model is thus relatively difficult. In practice, it is usually desirable to further simplify the structure of biological system models for the sake of reducing computation burden or simplification of the task of analysis. By introducing the technique of singular value decomposition it is possible to identify the major flux rate and hence deduce the corresponding signal transduction path. In this paper, a model reduction technique deduced from control theory is proposed to reduce that kind of systems.
Keywords :
biology; singular value decomposition; biochemical networks; biological system model; mathematical model; model reduction; singular value decomposition; Bioinformatics; Biological system modeling; Computational modeling; Mathematical model; Matrix decomposition; Reduced order systems; Steady-state; biochemical systems; linear system theory; model reduction;
Conference_Titel :
SICE Annual Conference 2010, Proceedings of
Conference_Location :
Taipei
Print_ISBN :
978-1-4244-7642-8