• DocumentCode
    529528
  • Title

    Model reduction of biochemical networks

  • Author

    Liu, Yen-Chang ; Lin, Chun-Liang

  • Author_Institution
    Dept. of Electr. Eng., Nat. Chung Hsing Univ., Taichung, Taiwan
  • fYear
    2010
  • fDate
    18-21 Aug. 2010
  • Firstpage
    3213
  • Lastpage
    3218
  • Abstract
    Biochemical networks are not only complex but also extremely large. The construction and analysis for the mathematical model is thus relatively difficult. In practice, it is usually desirable to further simplify the structure of biological system models for the sake of reducing computation burden or simplification of the task of analysis. By introducing the technique of singular value decomposition it is possible to identify the major flux rate and hence deduce the corresponding signal transduction path. In this paper, a model reduction technique deduced from control theory is proposed to reduce that kind of systems.
  • Keywords
    biology; singular value decomposition; biochemical networks; biological system model; mathematical model; model reduction; singular value decomposition; Bioinformatics; Biological system modeling; Computational modeling; Mathematical model; Matrix decomposition; Reduced order systems; Steady-state; biochemical systems; linear system theory; model reduction;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    SICE Annual Conference 2010, Proceedings of
  • Conference_Location
    Taipei
  • Print_ISBN
    978-1-4244-7642-8
  • Type

    conf

  • Filename
    5602849