Title :
Portable surface plasmon resonance instrument based on a monolithic scanner chip
Author :
Cai, Haoyuan ; Li, Hui ; Zhang, Lulu ; Chen, Xing ; Cui, Dafu
Author_Institution :
State Key Lab. of Transducer Technol., Chinese Acad. of Sci., Beijing, China
Abstract :
A portable Surface Plasmon Resonance (SPR) instrument based on a monolithic scanner chip-LM9833 was developed. With this compact design, the instrument can provide 16 bit grayscale resolution at 100 frames per second, support up to 16384 pixels linear CCD sensor, enable illumination control and USB interface. The instrument performance was tested and the refractive index sensitivity is about 6 × 10-5 RIU (Refractive Index Unit). A direct immunoassay was carried out with this instrument and 15μg/ml Human Serum Albumin (HSA) could be detected.
Keywords :
CCD image sensors; biosensors; monolithic integrated circuits; organic compounds; proteins; surface plasmon resonance; CCD sensor; Human Serum Albumin; LM9833 chip; USB interface; monolithic scanner chip; portable SPR instrument; portable surface plasmon resonance instrument; refractive index sensitivity; Charge coupled devices; Immune system; Instruments; Measurement by laser beam; Plasmons; Refractive index; Sensitivity; Biosensor; LM9833; Linear CCD; Surface Plasmon Resonance;
Conference_Titel :
Biomedical Engineering and Informatics (BMEI), 2010 3rd International Conference on
Conference_Location :
Yantai
Print_ISBN :
978-1-4244-6495-1
DOI :
10.1109/BMEI.2010.5639370
