Title :
A two-phase design for estimating the effective window of pharmaceutical response
Author :
Wang Dianpeng ; Tian Yubin
Author_Institution :
Dept. of Math., Beijing Inst. of Technol., Beijing, China
Abstract :
In pharmaceutical analysis, the window that cases effective response with probability larger than p is important and need to be precisely estimated. For this difficult issue, we propose a two-phase design by combining D-optimal strategy and likelihood recursive approximation to estimate it. Simulation study shows that the estimate is accurate and reliability.
Keywords :
maximum likelihood estimation; pharmaceuticals; recursive estimation; D-optimal strategy; effective pharmaceutical response window estimation; likelihood recursive approximation; pharmaceutical analysis; two phase design; Approximation methods; Biological system modeling; Computational modeling; Maximum likelihood estimation; Monte Carlo methods; Pharmaceuticals;
Conference_Titel :
Biomedical Engineering and Informatics (BMEI), 2010 3rd International Conference on
Conference_Location :
Yantai
Print_ISBN :
978-1-4244-6495-1
DOI :
10.1109/BMEI.2010.5639444
