DocumentCode :
534613
Title :
Distinct tissue responses to porous silk fibroin scaffolds (PSFSs) and polyvinyl alcohol (PVA) sponges in vivo
Author :
Guan, Guoping ; Bai, Lun ; Zuo, Baoqi ; Li, Mingzhong ; Wu, Zhengyu ; Lu Wang ; Li, Yonglin
Author_Institution :
Coll. of Textile & Clothing Eng., Soochow Univ., Suzhou, China
Volume :
4
fYear :
2010
fDate :
16-18 Oct. 2010
Firstpage :
1668
Lastpage :
1672
Abstract :
Selection of raw materials for biomedical materials has been one of the focuses on development of biomaterials. In this study, we used porous silk fibroin scaffolds (PSFSs) prepared by freeze drying method and polyvinyl alcohol (PVA) sponges which have similar macro-structure such as average pore size and porosity. Both materials were implanted in femoral muscles of rats, and the biocompatibility of both materials has been examined by histological observation and scoring method. Moreover, the biodegradation rates of both materials have been compared by a computer-assisted image analysis method. The results showed that PSFSs have better biocompatibility than PVA sponges in terms of deposition of collagen matrix, remodeling of extracellular matrix (ECM), infiltration of inflammatory cells, tissues formation and angiogenesis. However, PVA sponges evoked heavy and lasting infiltration of inflammatory cells, and the moderate infiltration lasted up to 23 days after the implantation. In summary, silk fibroin, as a natural protein, has incomparable biocompatibility for ECM organization and tissues formation, and thus has promising applications in tissue engineering and artificial organ.
Keywords :
biodegradable materials; biological tissues; biomedical materials; cellular biophysics; polymers; porosity; porous materials; proteins; tissue engineering; angiogenesis; artificial organ; average pore size; biocompatibility; biodegradation rates; biomedical materials; collagen matrix; computer-assisted image analysis method; extracellular matrix; femoral muscles; freeze drying method; histological observation; in vivo experiment; inflammatory cell infiltration; macrostructure; natural protein; polyvinyl alcohol sponges; porosity; porous silk fibroin scaffolds; rats; scoring method; time 23 day; tissue engineering; tissue formation; tissue responses; Biodegradation; Blood vessels; Materials; Muscles; Proteins; Rats; Tissue engineering; biocompatibility; biodegradation; polyvinyl alcohol(PVA); silk fibroin; tissue engineering;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Biomedical Engineering and Informatics (BMEI), 2010 3rd International Conference on
Conference_Location :
Yantai
Print_ISBN :
978-1-4244-6495-1
Type :
conf
DOI :
10.1109/BMEI.2010.5639621
Filename :
5639621
Link To Document :
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