Research on stimulus pattern for inhibition of detrusor hyperreflexia

The purpose of this study is to seek a new stimulus pattern, which stimulates pudendal nerve efficiently and reduces electrochemical damage, by means of investigating its influence on abolishing detrusor hyperreflexic contraction in bladder reflex pathway. For studying the mechanism of nerve conduction, a simulation system was built based on Frankenhaeuser-Huxley (FH) equations. With this system, we simulated responses of four kinds of pulse patterns, which were anodal pulse, cathodal pulse, biphasic symmetrical pulse and biphasic asymmetric pulse. After this simulation, we validated these results by stimulating the pudendal nerve of the Beagle dogs, spinal cord injured (SCI) models. The results showed that the charge-balanced stimulation would be possible by biphasic asymmetrical pulse, with the cathodal pulse in the front. In the animal experiments, this stimulus pattern was proved that it can abolish detrusor hyperreflexia efficiently.