Title :
Application of multi-centrality in human metabolism
Author :
De-Wu, Ding ; Xu-Dong, Liu
Author_Institution :
Dept. of Math. & Comput. Sci., Chizhou Coll., Chizhou, China
Abstract :
Lots of studies have focused on the structure and function of high-quality human metabolic networks. Recently, hub-based centrality is used to analysis of human metabolic network core. However, it is clear that this specific centrality measure is not sufficient alone. In the present paper, by comparing 10 different centrality measures with their application to human metabolic network core, be similar but smart, we give the top 10 center metabolites in the core, and discuss their biological and curatorial signification.
Keywords :
biochemistry; biocybernetics; molecular biophysics; network theory (graphs); network topology; centrality measure; high quality human metabolic network function; high quality human metabolic network structure; hub based centrality; human metabolic network core analysis; human metabolism; multicentrality; Computers; Diseases; Humans; Proteins; Publishing;
Conference_Titel :
Computational Intelligence and Natural Computing Proceedings (CINC), 2010 Second International Conference on
Conference_Location :
Wuhan
Print_ISBN :
978-1-4244-7705-0
DOI :
10.1109/CINC.2010.5643860
