Raman Microscopy and Imaging in Pharmaceutical Applications

Raman Microscopy and imaging can be used for a wide range of applications, such as the chemical identification of particles and smallest contaminations, the analysis of the distribution of a multitude of different components in a complex mixture. In recent years, the applications of Raman Microscopy and imaging in the pharmaceutical world, including capsules, packaging, coatings, sample homogeneity analysis, chemical composition, and combinatorial chemistry, has increased and is projected to continue increasing. After an introduction to the basic principles of Raman Microscopy and imaging, the developments of these methods and the application of Raman Microscopy and imaging in Process Analytical Technologies (PAT), Active Pharmaceutical Ingredient determination (API), and drug discovery and development will be reviewed.