Coupling the Guyton model to pulsatile ventricles using a multiresolution modelling environment

In this paper, we propose the substitution of the original, non-pulsatile cardiac sub-model of the Guyton model by an elastance-based pulsatile model of the heart, including interventricular interaction through the septum. Parameters of this cardiac model were identified by comparing the simulations obtained from the original Guyton model with those obtained from the proposed integrated, pulsatile model, during the 5 minutes simulation of a sudden severe muscle exercise. A close match is observed between the simulations obtained with the original and the pulsatile new model.