Fusion of MSCT imaging, Electro-Anatomical Mapping and Speckle Tracking Echocardiography for the characterization of local electro-mechanical delays in CRT optimization

In this work, we sought to assist the optimization of Cardiac Resynchronization Therapy (CRT) through the characterization of electro-mechanical delays for each region of the Left Ventricle. This characterization is based on the fusion of electrical, mechanical and anatomical data acquired from Electro-Anatomical Mapping (EAM), Speckle Tracking Echocardiography (STE) and Multislice CT (MSCT) imaging, respectively. Using MSCT as a reference, the first step is the registration of EAM 3D maps and STE 2D Contours on extracted MSCT LV-surfaces. After this registration step, local electrical and mechanical activation times can be displayed in the same space through 2D quantitative maps, therefore allowing the computation of local electro-mechanical delays. Local and global electro-mechanical delays from septal and lateral walls were calculated for three patients. The complementary information obtained may be useful for a better patient selection for CRT.