DocumentCode
544257
Title
Steric effects at acyclic and bridgehead carbons attached to carbonyls
Author
Kristol, David S. ; Fisher, Mark A. ; Yadav, Janardan ; Laxminarayan, Swamy ; Perlmutter, Howard
Author_Institution
New Jersey Inst. of Technol., Newark, NJ, USA
Volume
1
fYear
1992
fDate
Oct. 29 1992-Nov. 1 1992
Firstpage
211
Lastpage
212
Abstract
The rates of alkaline hydrolysis of seven acyclic and bridgehead esters of p-nitrophenyl carboxylic acids have been kinetically found to vary inversely with the size of the substituent R group. Computer assisted molecular modeling techniques were used to suggest a steric and electrostatic rationale for the effect of R group size upon the rate of hydrolysis.
Keywords
chemical reactions; chemistry computing; organic compounds; R group size; acyclic carbons; acyclic esters; alkaline hydrolysis; bridgehead carbons; carbonyls; electrostatic rationale; molecular modeling techniques; p-nitrophenyl carboxylic acids; steric effects;
fLanguage
English
Publisher
ieee
Conference_Titel
Engineering in Medicine and Biology Society, 1992 14th Annual International Conference of the IEEE
Conference_Location
Paris
Print_ISBN
0-7803-0785-2
Electronic_ISBN
0-7803-0816-6
Type
conf
DOI
10.1109/IEMBS.1992.5760930
Filename
5760930
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