The effect of respiration on the paced depolarization integral

The paced depolarization integral is the integral of the paced electrogram at the pacing site during ventricular depolarization. The paced depolarization integral has been used as a rate control parameter for a rate responsive pacemaker. Studies also have shown that the paced depolarization integral has the potential to be used for tachyarrhythmia differentiation. In this study, the effect of positive pressure respiration on the paced depolarization integral was investigated. It was found that the paced depolarization integral could be modulated significantly by changing the ventilation modes in animals.