Title :
Long range correlations in healthy dynamics and their breakdown with disease: A new paradigm for physiological monitoring
Author :
Goldberger, Ary L. ; Peng, Chung-Kang ; Mietus, Joseph ; Hausdorff, Jeffrey M. ; Havlin, Shlomo ; Stanley, H. Eugene
Author_Institution :
Cardiovascular Div., Beth Israel Hosp., Boston, MA, USA
fDate :
Oct. 29 1992-Nov. 1 1992
Abstract :
We propose a new framework for conceptualizing and quantitating the dynamics of health and disease, using neuroautonomic regulation of the heartbeat as a model system. This theory is based on two postulates: 1) Complex physiological systems operate far from equilibrium and demonstrate long-range correlations indicative of a fractal (scale-invariant) mechanism; 2) Pathologic dynamics are marked by a breakdown in this long- range correlation behavior.
Keywords :
cardiology; diseases; neurophysiology; patient monitoring; physiological models; complex physiological systems; disease; fractal mechanism; health; healthy dynamics; long-range correlations; neuroautonomic regulation; pathologic dynamics; physiological monitoring; scale-invariant mechanism; Cardiology; Pathology;
Conference_Titel :
Engineering in Medicine and Biology Society, 1992 14th Annual International Conference of the IEEE
Conference_Location :
Paris
Print_ISBN :
0-7803-0785-2
Electronic_ISBN :
0-7803-0816-6
DOI :
10.1109/IEMBS.1992.5761330
