Time delay estimation of evoked potentials by generalized cross-correlation

In this paper, we use the generalized cross-correlation method to estimate time delay between evoked potentials (EP) present in two individual sweeps. The generalized cross-correlation differs from classical cross-correlation by pre-filtering the signal. The aim of this work is to investigate the performance of this method for different pre-filters proposed in the literature. We show that the filter which minimizes the mean square estimation error gives the better result when the EP spectrum is partially unknown.