Title :
Biosensor using shear-horizontal surface acoustic wave
Author :
Yatsuda, H. ; Kogai, T. ; Goto, M. ; Chard, M. ; Athey, D.
Author_Institution :
Japan Radio Co. Ltd., Fujimino, Japan
Abstract :
This paper describes an immunoassay-based biosensor which is composed of a disposable sensor device and a prototype electric reader with 14 × 10 × 4 cm3 in size. The sensor devices are fabricated using a 250 MHz shear horizontal surface acoustic wave (SH-SAW) delay-line on quartz substrates, which is composed of a transmitting interdigital transducer (IDT), receiving IDT, and a biochemical reaction area between them. The biochemical reaction area is covered with antibodies. The electric reader is connected to the sensor device and detects antigen-antibody reactions. The reader has a burst circuit to eliminate unwanted electro-magnetic feed through signals. A model immunoassay based upon human serum albumin detection is presented. A model assay system for the sensitive measurement of human C reactive protein (C-RP) is also shown.
Keywords :
biomedical measurement; biosensors; interdigital transducers; proteins; surface acoustic wave delay lines; surface acoustic wave sensors; surface acoustic wave transducers; SH-SAW delay-line; antigen-antibody reactions; biochemical reaction area; disposable sensor device; electric reader; electromagnetic feed; frequency 250 MHz; human C reactive protein sensitive measurement; human serum albumin detection; immunoassay-based biosensor; model assay system; prototype electric reader; quartz substrates; receiving IDT; shear-horizontal surface acoustic wave delay line; transmitting interdigital transducer; Biosensors; Films; Gold; Humans; Immune system; Proteins; Surface acoustic waves;
Conference_Titel :
Microwave Conference Proceedings (CJMW), 2011 China-Japan Joint
Conference_Location :
Hangzhou
Print_ISBN :
978-1-4577-0625-7
Electronic_ISBN :
978-7-308-08555-7
