Title :
Notice of Retraction
Effect of DEHP on Learning and Memory Ability of Kunming Mice
Author :
Jiaqi Tang ; Ye Yuan ; Jing Guo ; Xiaomei Liao ; Xu Yang
Author_Institution :
Hubei Key Lab. of Genetic Regul. & Integrative Biol., Central China Normal Univ., Wuhan, China
Abstract :
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
Di (2-ethylhexyl) phthalate (DEHP) was used in the plastic industry and widely distributed in the environment, which might cause adverse effects to living organisms. To study the effects of DEHP on learning and memory, the KM mice were exposed to different concentrations of DEHP (0, 5, 50 and 500 mg/kg·d) for fourteen days. With the exposed, the Morris water maze was used to test the learning abilities of mice in the 1st to the 10th day, and the memory by probe trial test in the 14th day. Then the reactive oxygen species (ROS) and malondialdehyde (MDA) content of brains were measured. The results showed that with the increase of DEHP concentrations, increasing of ROS and MDA contents were observed, and the learning abilities and memory were reduced. These results suggested that DEHP could induce the acute oxidative damage in brains of mice, and have negative effects on the learning abilities and memory.
Keywords :
biotechnology; brain; plastics industry; Kunming mice learning ability; Kunming mice memory ability; living organisms; malondialdehyde content; mice brains; plastic industry; reactive oxygen species; Chemicals; Humans; Laboratories; Mice; Pediatrics; Stress;
Conference_Titel :
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location :
Wuhan
Print_ISBN :
978-1-4244-5088-6
DOI :
10.1109/icbbe.2011.5781374