Title :
Control-Relevant Erythropoiesis Modeling in End-Stage Renal Disease
Author :
Chait, Yossi ; Horowitz, Joseph ; Nichols, Brendan ; Shrestha, Rajiv P. ; Hollot, C.V. ; Germain, Michael J.
Author_Institution :
Dept. of Mech. & Ind. Eng., Univ. of Massachusetts Amherst, Amherst, MA, USA
Abstract :
Anemia is prevalent in end-stage renal disease (ESRD). The discovery of recombinant human erythropoietin (rHuEPO) over 30 years ago has shifted the treatment of anemia for patients on dialysis from blood transfusions to rHuEPO therapy. Many anemia management protocols (AMPs) used by clinicians comprise a set of experience-based rules for weekly-to-monthly titration of rHuEPO doses based on hemoglobin (Hb) measurements. In order to facilitate the design of an AMP using model-based feedback control theory, we present a physiologically relevant erythropoiesis model and demonstrate its applicability using clinical data.
Keywords :
blood; cellular biophysics; diseases; lung; molecular biophysics; patient treatment; proteins; anemia management protocols; anemia patient treatment; blood transfusions; clinical data; control-relevant erythropoiesis modeling; dialysis; end-stage renal disease; hemoglobin measurements; model-based feedback control theory; physiological relevant erythropoiesis model; rHuEPO therapy; recombinant human erythropoietin; Data models; Diseases; Estimation; Mathematical model; Physiology; Production; Training; Anemia of chronic kidney disease (CKD); end-stage renal disease (ESRD); pharmacokinetic/pharmacodynamic modeling; recombinant human erythropoietin (rHuEPO);
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2013.2286100
