Control-Relevant Erythropoiesis Modeling in End-Stage Renal Disease

Author

Chait, Yossi ; Horowitz, Joseph ; Nichols, Brendan ; Shrestha, Rajiv P. ; Hollot, C.V. ; Germain, Michael J.

Author_Institution

Dept. of Mech. & Ind. Eng., Univ. of Massachusetts Amherst, Amherst, MA, USA

Volume

61

Issue

3

fYear

2014

fDate

Mar-14

Firstpage

658

Lastpage

664

Abstract

Anemia is prevalent in end-stage renal disease (ESRD). The discovery of recombinant human erythropoietin (rHuEPO) over 30 years ago has shifted the treatment of anemia for patients on dialysis from blood transfusions to rHuEPO therapy. Many anemia management protocols (AMPs) used by clinicians comprise a set of experience-based rules for weekly-to-monthly titration of rHuEPO doses based on hemoglobin (Hb) measurements. In order to facilitate the design of an AMP using model-based feedback control theory, we present a physiologically relevant erythropoiesis model and demonstrate its applicability using clinical data.

Keywords

blood; cellular biophysics; diseases; lung; molecular biophysics; patient treatment; proteins; anemia management protocols; anemia patient treatment; blood transfusions; clinical data; control-relevant erythropoiesis modeling; dialysis; end-stage renal disease; hemoglobin measurements; model-based feedback control theory; physiological relevant erythropoiesis model; rHuEPO therapy; recombinant human erythropoietin; Data models; Diseases; Estimation; Mathematical model; Physiology; Production; Training; Anemia of chronic kidney disease (CKD); end-stage renal disease (ESRD); pharmacokinetic/pharmacodynamic modeling; recombinant human erythropoietin (rHuEPO);

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/TBME.2013.2286100

Filename

6634219