Title :
Design of Robust Metabolic Pathways
Author :
Umeton, Renato ; Stracquadanio, Giovanni ; Sorathiya, Anilkumar ; Papini, Alessio ; Liò, Pietro ; Nicosia, Giuseppe
Author_Institution :
Dept. of Biol. Eng., MIT, Cambridge, MA, USA
Abstract :
In this paper we investigate plant photosynthesis and microbial fuel cells. We report the following: 1) we introduce and validate a novel multi-objective optimization algorithm, PMO2; 2) in photosynthesis we increase the yield of 135%, while in Geobacter sulfurreducens we determine the tradeoff for growth versus redox properties; 3) finally, we discuss Pareto-Front as an estimator of robust metabolic pathways.
Keywords :
biochemistry; biotechnology; botany; chemical reactions; fuel cells; optimisation; photosynthesis; Geobacter sulfurreducens; PMO2; Pareto-front; microbial fuel cells; multiobjective optimization algorithm; plant photosynthesis; redox properties; robust metabolic pathways; Algorithm design and analysis; Carbon; Nitrogen; Optimization; Proteins; Robustness; Carbon metabolism; Geobacter sulfurreducens; Metabolic engineering; Multi-objective Optimization; Mutational Robustness;
Conference_Titel :
Design Automation Conference (DAC), 2011 48th ACM/EDAC/IEEE
Conference_Location :
New York, NY
Print_ISBN :
978-1-4503-0636-2
