• DocumentCode
    551873
  • Title

    The analysis on fluorescence signals of the multi-channel DNA analyzer

  • Author

    Fang, Yi ; Wang, Liqiang ; Xu, Jin ; Wang, Pengpeng ; Yan, Huimin

  • Author_Institution
    State Key Lab. of Modern Opt. Instrum., Zhejiang Univ., Hangzhou, China
  • Volume
    3
  • fYear
    2011
  • fDate
    29-31 July 2011
  • Abstract
    The original data generated by multi-channel DNA analyzer is a mixture in time domain of data of multiple channels and that of multiple spectra. Thus, it is necessary to preprocess the original data before the DNA sequence can be identified. In this paper, the processing procedure is proposed, including choosing data segment, deburring, generating four-color information, choosing channels, data filtering and removing baseline. The experiment results state that useful information can be well separated from original data. The noise is greatly reduced and signal peaks are clearer. And that will provide the basis for determining the type and position of bases.
  • Keywords
    DNA; bioinformatics; biological techniques; data analysis; fluorescence spectroscopy; molecular biophysics; signal processing; spectral analysis; DNA sequence; baseline removal; channel choosing; data filtering; data preprocessing; data segment choosing; data time domain; deburring; fluorescence signal analysis; four color information generation; multichannel DNA analyzer; multiple channels; multiple spectra; Computers; Educational institutions; Filtering; Noise; data filtering; deburring; fluorescence signals; four-color; removing baseline;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Electronics and Optoelectronics (ICEOE), 2011 International Conference on
  • Conference_Location
    Dalian
  • Print_ISBN
    978-1-61284-275-2
  • Type

    conf

  • DOI
    10.1109/ICEOE.2011.6013373
  • Filename
    6013373