Effect of pH on optical properties during blood coagulation progress by optical coherence tomography

Author

Fu, Feifei ; Lin, Jia ; Xu, Xiangqun

Author_Institution

Sch. of Sci., Zhejiang Sci-Tech Univ., Hangzhou, China

Volume

1

fYear

2011

fDate

15-17 Oct. 2011

Firstpage

268

Lastpage

271

Abstract

Optical coherence tomography (OCT) has been used to evaluate blood coagulation process and is proved efficiently by using OCT signal slope and 1/e light penetration depth (D_1/e). The purpose of this study is to investigate the effect of pH on the two optical properties of whole blood during in vitro clot formation under static by optical coherence tomography. After the addition of 0.9% (w/v) sodium chloride solution with pH=6, 7, 8, 9, OCT signal slope (OCTSS) have a total decrease of 6.98%, 4.07%, 4.16%, 3.69% after 60-min coagulation, and the blood clotting time are 985, 1041, 1065, 967, respectively. Our results suggest that when blood pH was lower or higher than normal value, the blood clotting time shows a decrease and the process of blood coagulation appears abnormal.

Keywords

biochemistry; blood; coagulation; optical tomography; pH; refractive index; blood coagulation progress; in vitro clot formation; light penetration depth; optical coherence tomography; optical properties; pH effects; refractive index; sodium chloride solution addition; Biomedical optical imaging; Coagulation; Optical imaging; Optical refraction; Optical scattering; Optical variables control; Optical coherence tomography; blood coagulation; blood pH; optical parameters;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering and Informatics (BMEI), 2011 4th International Conference on

Conference_Location

Shanghai

Print_ISBN

978-1-4244-9351-7

Type

conf

DOI

10.1109/BMEI.2011.6098273

Filename

6098273