Functional characterization of hub proteins in weighted yeast protein-protein interaction networks

Author

Yun-yuan, Dong ; Qi-jun, Liu ; Jun, Yang ; Yong-xian, Wang ; Zheng-hua, Wang

Author_Institution

Coll. of Comput., Nat. Univ. of Defense Technol., Changsha, China

Volume

3

fYear

2011

fDate

15-17 Oct. 2011

Firstpage

1729

Lastpage

1732

Abstract

The centrality-lethality rule reveals that topological prominence of a protein indicates its functional importance. But are all hub proteins in PPI network essential? Using P-value to weight PPI networks, we classified hub proteins into two types: essential hub and nonessential hub. The weighted centrality measure of weighted PPI networks showed that the weighted method can give greater support for functional characterization of hub proteins. We found that essential hubs are vital and they tend to be intra-modular hubs, while nonessential hubs are useful in maintaining the overall network connectivity and tend to be inter-modular hubs.

Keywords

molecular biophysics; proteins; topology; centrality-lethality rule; functional characterization; hub proteins; topological prominence; weighted yeast protein-protein interaction networks; Bioinformatics; Correlation; Educational institutions; Genomics; Organisms; Proteins; Weight measurement; essential hub; nonessential hub; weighted centrality; weighted protein-protein interaction network;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering and Informatics (BMEI), 2011 4th International Conference on

Conference_Location

Shanghai

Print_ISBN

978-1-4244-9351-7

Type

conf

DOI

10.1109/BMEI.2011.6098526

Filename

6098526