Simulation based bio engineering and science: From protein dynamics to DNA tile design

In this paper, we briefly summarize the history of elastic network model (ENM) as a useful atomistic modeling tool for biosystems. Various ENMs have been developed and mainly applied to the study on protein dynamics. Recently, its application area was extended to nano structure design and analysis. ENM based normal mode analysis and geometric interpolation method explain well not only the relationship between structure and function of proteins, but also the mechanism of self-assembly of DNA tiles in a solution. This computationally adequate and effective tool will play an important role in the area of “simulation based bio engineering and science”.